(±)-Lisofylline

Name: (±)-Lisofylline
Brand: GlpBio
SKU: GC90005
Availability: InStock
Rating: 5 (30 reviews)

Catalog No.GC90005

Un potente inhibidor de la generación de ácido fosfatídico.

Products are for research use only. Not for human use. We do not sell to patients.

(±)-Lisofylline Chemical Structure

Cas No.: 6493-06-7

Tamaño

Precio

Disponibilidad

Cantidad

10 mg	102,00 $	Disponible
25 mg	164,00 $	Disponible
50 mg	310,00 $	Disponible
100 mg	549,00 $	Disponible

Tel：(909) 407-4943 Email: sales@glpbio.com

Reseñas de cliente

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.

GlpBio Products Cited In Reputable Papers

Nature
610.7931 (2022): 366-372

Nature
618, 1017–1023 (2023)

Cell
183.7 (2020): 1867-1883

Cell Research
31, 1291–1307 (2021)

Cell Research
33, 273–287 (2023)

Cell Research
33, 546–561 (2023)

Molecular Cancer
21.1 (2022): 1-17

Molecular Cancer
21.1 (2022): 1-18

Cancer Cell
39 (2021): 1-16

Cell Host Microbe
30.8 (2022): 1124-1138

Cell Host Microbe
31.5 (2023): 766-780

Cell Host Microbe
31.3 (2023): 418-43

Cell Metabolism
34.2 (2022): 240-255

Ann Rheum Dis
82(4): 533-545 (2023)

Cell Mol Immunol
20, 264–276 (2023)

Adv Funct Mater
33.35 (2023): 2214998

Description Chemical Properties Product Documents

Product Documents

Quality Control & SDS

View current batch:

Purity: >98.00%

(±)-Lisofylline (LSF) is a potent anti-inflammatory agent in which only the (−) optical isomer is biologically active.^1,2 LSF inhibits the generation of phosphatidic acid (IC₅₀ = 0.6 µM) from cytokine-activated lysophosphatidic acyl transferase (LPAAT), which has been shown to protect mice from endotoxic shock.³ LSF suppresses the production of the proinflammatory cytokine IFN-γ, inhibits IL-12-mediated STAT-4 activation, and enhances glucose-stimulated β-cell insulin secretion, reducing the onset of diabetes in a non-obese diabetic mouse model.^1,4

Cas No.	6493-06-7	SDF
Formula	C₁₃H₂₀N₄O₃	M.Wt	280.3
Solubility	DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 2 mg/ml,PBS (pH 7.2): 1 mg/ml	Storage	Store at -20°C
General tips	Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition	Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
		1 mg	5 mg	10 mg
	1 mM	3.5676 mL	17.838 mL	35.6761 mL
	5 mM	0.7135 mL	3.5676 mL	7.1352 mL
	10 mM	0.3568 mL	1.7838 mL	3.5676 mL

Molarity Calculator
Dilution Calculator
Molecular Weight Calculator

Calculate

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal:μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reseñas

Review for (±)-Lisofylline

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

5 Star

100%

4 Star

3 Star

2 Star

1 Star

Review for (±)-Lisofylline

GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.

Required fields are marked with *

Overall Rating

★

Review Title

Reseña

Apodo

Correo electrónico

You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

(±)-Lisofylline

Reseñas de cliente

GlpBio Citations

Bioactive Compounds Premium Provider

GlpBio Products Cited In Reputable Papers

Product Documents

Quality Control & SDS

Complete Stock Solution Preparation Table

Molarity Calculator

Dilution Calculator

Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Reseñas