2,3-dinor-6-keto Prostaglandin F1α-d9 (sodium salt) (Synonyms: 2,3dinor6keto PGF1αd9 (sodium salt))

An internal standard for the quantification of 2,3-dinor-6-keto Prostaglandin F_1α by GC- or LC-MS. 2,3-dinor-6-keto prostaglandin F_1α (2,3-dinor-6-keto PGF_1α) is the β-oxidation product of 6-keto PGF_1α and the major urinary metabolite of PGI₂ in humans.^1,2 2,3-dinor-6-keto PGF_1α makes up 23% of the recovered radioactivity in urine after administration of labeled 6-keto PGF_1α and 20.5% after administration of labeled PGI₂.² In healthy human subjects, the average excreted 2,3-dinor-6-keto PGF_1α level is ~100 pg/mg creatinine.³

1.Fitzgerald, G.A., Lawson, J., Blair, I.A., et al.Analysis of urinary metabolites of thromboxane and prostacyclin by negative-ion chemical-ionization gas chromatography/mass spectrometryAdvances in Prostaglandin, Thromboxane, and Leukotriene Research1587-90(1985) 2.Rosenkranz, B., Fischer, C., Reimann, I., et al.Identification of the major metabolite of prostacyclin and 6-ketoprostaglandin F1α in manBiochimica et Biophysica Acta619207-213(1980) 3.Wennmalm, Å., Benthin, G., GranstrÖm, E.F., et al.2,3-Dinor metabolites of thromboxane A2 and prostacyclin in urine from healthy human subjects: Diurnal variation and relation to 24h excretionClinical Science83461-465(1992)