2-(cyclohexylmethyl)-Plumbagin |
| Catalog No.GC91106 |
Un derivado de plumbagina.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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2-(cyclohexylmetl)-Plumbagin is a derivative of the naphthoquinone plumbagin .1 It is selectively cytotoxic to PANC-1 human pancreatic cancer cells under nutrient-deprived conditions, which mimic the microenvironment of pancreatic cancer tumors, over PANC-1 cells under nutrient-rich conditions with 50% preferential cytotoxicity values (PC50s) of 0.11 and 47.2 µM, respectively. It also induces apoptosis in PANC-1 cells when used at a concentration of 1 µM. 2-(cyclohexylmetl)-Plumbagin also selectively reduces phosphorylation of Akt and mammalian target of rapamycin (mTOR) in PANC-1 cells under nutrient-deprived, but not nutrient-rich, conditions. It reduces tumor volume and weight in a MiaPaCa-2 pancreatic cancer mouse xenograft model when administered at doses of 50 and 250 µg/animal five times per week.
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