3-Phosphoglyceric acid |
| Catalog No.GC70376 |
3-Phosphoglyceric acid es un intermediario metabólico tanto en la glucólisis como en el ciclo de Calvin.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 820-11-1
Sample solution is provided at 25 µL, 10mM.
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3-Phosphoglyceric acid (400 µM; 24 hours; BMDMs) treatment enhances Spp1 transcription in VHL-deficient macrophages, and the reduced H3K4me3 modification is also reversed[1].
3-Phosphoglyceric treatment significantly augmentes gene expression as well as H3K4me3 deposition of Spp1 in IL-4-stimulated macrophages[1].
In yeast, 3-Phosphoglyceric acid acts as a metabolic checkpoint for the formation of a multicomponent enzyme complex including serine metabolic enzymes and pyruvate kinase isoform 2 (PKM2) homologue, which senses both serine metabolism and glycolysis and regulates H3K4 methylation and histone phosphorylation[1].
References:
[1]. Zhang W, et al. The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation. J Exp Med. 2018 Dec 3;215(12):3180-3193.
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