6-NBDG (Synonyms: 6-NBD-Glucose) |
| Catalog No.GC18870 |
El 6-NBDG es un anÁlogo de glucosa fluorescente que se puede utilizar para obtener imÁgenes de fluorescencia y controlar el transporte y la captaciÓn de glucosa.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 108708-22-1
Sample solution is provided at 25 µL, 10mM.
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6-NBDG is a non-hydrolyzable fluorescent glucose analog that is used to monitor glucose uptake and transport in living cells. 6-NBDG has been validated as a probe for the glucose transporter GLUT1 in cells. The fluorophore NBD displays excitation/emission maxima of 465/535 nm.
References:
1. Hansen, T.V.A., Hansen, M., Nejsum, P., et al. Glucose absorption by the bacillary band of Trichuris muris PLoS Negl. Trop. Dis. 10(9), e0004971 (2016).
2. Wang, M.S., Luo, Z., and Nitin, N. Rapid assessment of drug response in cancer cells using microwell array and molecular imaging Anal. Bioanal. Chem. 406(17), 4195-4206 (2014).
3. Zaman, R.T., Kosuge, H., Pratx, G., et al. Fiber-optic system for dual-modality imaging of glucose probes 18F-FDG and 6-NBDG in atherosclerotic plaques PLoS One 9(9), e108108 (2014).
4. Barros, L.F., Bittner, C.X., Loaiza, A., et al. Kinetic validation of 6-NBDG as a probe for the glucose transporter GLUT1 in astrocytes J. Neurochem. 109(Suppl 1), 94-100 (2009).
| Cas No. | 108708-22-1 | SDF | |
| Sinónimos | 6-NBD-Glucose | ||
| Chemical Name | 6-deoxy-6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose | ||
| Canonical SMILES | O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)O[C@@H]1CNC2=CC=C([N+]([O-])=O)C3=NON=C23 | ||
| Formula | C12H14N4O8 | M.Wt | 342.3 |
| Solubility | DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: slightly soluble,PBS (pH 7.2): 10 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.9214 mL | 14.6071 mL | 29.2141 mL |
| 5 mM | 0.5843 mL | 2.9214 mL | 5.8428 mL |
| 10 mM | 0.2921 mL | 1.4607 mL | 2.9214 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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