7-Methoxy-4-(trifluoromethyl)coumarin (Synonyms: MFC) |
| Catalog No.GC49248 |
A fluorogenic substrate for CYPs
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 575-04-2
Sample solution is provided at 25 µL, 10mM.
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7-Methoxy-4-(trifluoromethyl)coumarin is a fluorogenic substrate for cytochrome P450s (CYPs).1 Upon enzymatic cleavage by CYPs, 7-hydroxy-4-(trifluoromethyl)coumarin (HFC) is released and its fluorescence can be used to quantify CYP activity. HFC displays excitation/emission maxima of 410/510 nm, respectively.
1.Donato, M.T., JimÉnez, N., Castell, J.V., et al.Fluorescence-based assays for screening nine cytochrome P450 (P450) activities in intact cells expressing individual human P450 enzymesDrug Metab. Dispos.32(7)699-706(2004)
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