8-Chloroadenosine-5'-triphosphate (sodium salt) |
| Catalog No.GC90841 |
Un metabolito activo de 8-cloro cAMP.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 793671-47-3
Sample solution is provided at 25 µL, 10mM.
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8-Chloroadenosine-5’-triphosphate (8-chloro ATP) is an active metabolite of the anticancer agent 8-chloro cAMP and a derivative of the nucleotide adenosine 5’-triphosphate .1 It is formed from 8-chloro cAMP via 8-chloroadenosine and mono- and diphosphate intermediates. 8-chloro ATP accumulates for up to 12 hours following application of 8-chloro cAMP or 8-chloroadenosine and is associated with inhibition of cell growth, decreases in endogenous ATP levels, and a reduction in RNA, but not DNA, synthesis in patient-derived multiple myeloma cells. It inhibits topoisomerase II-α-dependent relaxation of supercoiled pUC19 DNA when used at concentrations of 1.5 to 8 mM, as well as reduces topoisomerase II-α-catalyzed ATP drolysis by 50% at 1 mM, in K562 human myelocytic leukemia cells.2
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