A2764 dihydrochloride |
| Catalog No.GC39335 |
El diclorhidrato de A2764 es un inhibidor altamente selectivo de TRESK (canal K+ de la médula espinal relacionado con TWIK, K2P18.1), que tiene efectos inhibidores moderados sobre TREK-1 y TALK-1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 861038-72-4
Sample solution is provided at 25 µL, 10mM.
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A2764 dihydrochloride is a highly selective inhibitor of TRESK (TWIK-related spinal cord K+ channel, K2P18.1), which has moderate inhibitory effects on TREK-1 and TALK-1. A2764 dihydrochloride is more sensitive to the activated mTRESK channels (IC50=6.8 μM) than the basal current. A2764 dihydrochloride can lead to cell depolarization and increased excitability in native cells, it has the potential for probing the role of TRESK channel in migraine and nociception[1].
[1]. Lengyel M, et al. Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K2P18.1) Background Potassium Channel.Mol Pharmacol. 2019 Jun;95(6):652-660.
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