Actoxumab |
| Catalog No.GC72349 |
Actoxumab (Anti-C. Toxina difficile (un anticuerpo recombinante) es un anticuerpo antitoxina contra C. difficile toxina A neutralizando TcdA.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1245634-25-6
Sample solution is provided at 25 µL, 10mM.
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Actoxumab (10 mg/kg WT or N297Q mutant (N297Q) actoxumab-bezlotoxumab; 2 h plus 24 h) significantly inhibits cell rounding activity in Vero cells under 2 ng/mL TcdA treatment[1].
Actoxumab (0.1-10 mg/kg or 50 mg/kg; i.p.; single dose) shows protective effect in multiple murine models of clostridium difficile infection (CDI), including systemic and local (gut) toxin challenge models, as well as primary and recurrent models of infection in mice[1].
Actoxumab shows a synergy with Bezlotoxumab, and (combination dosage of 3, 30, 300 μg/mouse; i.p.; single dose) prevents both epithelial damage and inflammatory disease[1].
References:
[1]. Yang Z, et al. Mechanisms of protection against Clostridium difficile infection by the monoclonal antitoxin antibodies actoxumab and bezlotoxumab. Infect Immun. 2015 Feb;83(2):822-31.
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