Allocholic acid (Synonyms: ACA, AlloCA, allo-Cholic Acid, 5α-Allocholic Acid) |
| Catalog No.GC60044 |
El Ácido alocÓlico es un Ácido biliar tÍpicamente fetal que se encuentra en los vertebrados y reaparece durante la regeneraciÓn del hÍgado y la carcinogénesis, ademÁs también es un Ácido conjugado del alocolato y un isÓmero del Ácido cÓlico. El Ácido alocÓlico es un estimulante potente y especÍfico del sistema olfativo adulto, tiene un papel como metabolito marino, metabolito de rata y metabolito humano.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2464-18-8
Sample solution is provided at 25 µL, 10mM.
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Allocholic acid(3α, 7α, 12α-trihydroxy-5α-cholic acid(ACA)), Allocholic acid is a conjugated and isomer of isocholic acid. Allocholic acid is found in vertebrates, some mammals, and humans and occurs during liver regeneration and carcinogenesis. It has been suggested to function as a migratory pheromone in some migratory fish species, such as the sea lamprey [1-4]. Allocholic acid concentrations are typically low or undetectable in healthy adults but elevated in fetuses, infants, pregnant women, certain malignancies, and during liver regeneration [5-7]. Compared to its 5β differential isome-Major bile acids (BAs), allocholic acid induces a more pronounced cholestatic effect, leading to enhanced bile flow [8].
Allocholic acid(100mg/kg; i.g; 14days) treated normal mice at high doses without causing liver damage for 14 days. Allocholic acid(25-100mg/kg; i.g; 14days) pretreatments substantially alleviated the necrosis of hepatocytes and significantly reduced the elevated aspartate aminotransferase (AST), alkaline phosphatase (ALP), and direct bilirubin (DBIL) levels brought on by ANIT. Allocholic acid may protect mice from ANIT-induced cholestasis with liver injury[9].
References:
[1]. Elliott, W. H. (1971). Allo bile acids. In P. P. Nair & D. Kritchevsky (Eds.), The bile acids chemistry, physiology, and metabolism (pp. 47–93). Springer, Boston, MA.
[2]. Yamasaki K, Ayaki Y, et,al. Allocholic acid, a metabolite of 7 -hydroxycholesterol in the rat and rabbit. J Biochem. 1972 May;71(5):927-9. doi: 10.1093/oxfordjournals.jbchem.a129848. PMID: 5073332.
[3]. Li W, Sorensen PW, et,al. The olfactory system of migratory adult sea lamprey (Petromyzon marinus) is specifically and acutely sensitive to unique bile acids released by conspecific larvae. J Gen Physiol. 1995 May;105(5):569-87. doi: 10.1085/jgp.105.5.569. PMID: 7658193; PMCID: PMC2216950.
[4]. Briggs T, Bussjaeger C. Allocholic acid, the major component in bile from the river carpsucker, Carpiodes carpio (Rafinesque) (Catostomidae). Comp Biochem Physiol B. 1972 Jul 15;42(3):493-6. doi: 10.1016/0305-0491(72)90264-7. PMID: 4644219.
[5]. Mendoza ME, Monte MJ, et,al. Physiological characteristics of allo-cholic acid. J Lipid Res. 2003 Jan;44(1):84-92. doi: 10.1194/jlr.m200220-jlr200. PMID: 12518026.
[6]. Kimura A, Mahara R, et,al. Profile of urinary bile acids in infants and children: developmental pattern of excretion of unsaturated ketonic bile acids and 7beta-hydroxylated bile acids. Pediatr Res. 1999 Apr;45(4 Pt 1):603-9. doi: 10.1203/00006450-199904010-00022. PMID: 10203155.
[7]. Mendoza, M. E., et,al. Changes in the pattern of bile acids in the nuclei of rat liver cells during hepatocarcinogenesis. Clinical Science, 102(2), 143–150. https://doi.org/10.1042/cs1020143
[8]. Mendoza ME, Monte MJ, et,al. Physiological characteristics of allo-cholic acid. J Lipid Res. 2003 Jan;44(1):84-92. doi: 10.1194/jlr.m200220-jlr200. PMID: 12518026.
[9]. Han X, Lin C, et,al. Allocholic acid protects against α-naphthylisothiocyanate-induced cholestasis in mice by ameliorating disordered bile acid homeostasis. J Appl Toxicol. 2024 Apr;44(4):582-594. doi: 10.1002/jat.4562. Epub 2023 Nov 15. PMID: 37968239.
| Animal experiment [1]: | |
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Animal models |
Male C57BL/six mice (8 weeks old) |
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Preparation Method |
α-naphthylisothiocyanate (ANIT) modeling achieved cholestasis in mice, and Allocholic acid was administered to mice at different doses for 14 days. |
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Dosage form |
25-100mg/kg; i.g; 14days |
|
Applications |
Allocholic acid treatment alleviates liver damage in ANIT-induced cholestatic mice. |
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References: |
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| Cas No. | 2464-18-8 | SDF | |
| Sinónimos | ACA, AlloCA, allo-Cholic Acid, 5α-Allocholic Acid | ||
| Canonical SMILES | C[C@H](CCC(O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C | ||
| Formula | C24H40O5 | M.Wt | 408.57 |
| Solubility | DMSO: 125 mg/mL (305.95 mM) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.4476 mL | 12.2378 mL | 24.4756 mL |
| 5 mM | 0.4895 mL | 2.4476 mL | 4.8951 mL |
| 10 mM | 0.2448 mL | 1.2238 mL | 2.4476 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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