AMG-1694 |
| Catalog No.GC70590 |
AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1361217-07-3
Sample solution is provided at 25 µL, 10mM.
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AMG-1694 is highly effective in restoring the enzymatic activity of GK with an EC50 of 0.020 μM in the presence of GKRP[1].
References:
[1]. Lloyd DJ, et al. Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors. Nature. 2013 Dec 19;504(7480):437-40.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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