Aminooxy-PEG2-azide |
| Catalog No.GC66322 |
Aminooxy-PEG2-azide es un conector PROTAC basado en PEG que se puede utilizar en la sÍntesis de PROTAC. La aminooxi-PEG2-azida también es un conector ADC de PEG de 2 unidades no escindible que se utiliza en la sÍntesis de conjugados de anticuerpo-fÁrmaco (ADC).
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Cas No.: 1043426-13-6
Sample solution is provided at 25 µL, 10mM.
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Aminooxy-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Aminooxy-PEG2-azide is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
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