BCRP-IN-1 |
| Catalog No.GC33099 |
BCRP-IN-1 es un inhibidor de la proteÍna resistente al cÁncer de mama (BCRP) con una IC50 de 0,6 μM en el transportador de salida de BCRP.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1699720-85-8
Sample solution is provided at 25 µL, 10mM.
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BCRP-IN-1 is a breast cancer resistance protein (BCRP) inhibitor with an IC50 of 0.6 μM on BCRP efflux transporter.
BCRP-IN-1 (Compound A) shows the potency and a potent pharmacokinetic (PK) profile in rats (lower clearance [1.54 L/h/kg] and higher bioavailability [123%]). XL388 has moderate terminal elimination half-life with t1/2s of 0.9 h and 2.0 h for 2 mg/kg (iv) and 20 mg/kg (po) in rats, respectively[1].
[1]. Li Y, et al. Synthesis of a new inhibitor of breast cancer resistance protein with significantly improved pharmacokinetic profiles. Bioorg Med Chem Lett. 2016 Jan 15;26(2):551-555.
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