BI-6C9 |
| Catalog No.GC41252 |
BI-6C9 es un inhibidor del dominio de interacciÓn BH3 altamente especÍfico (Bid), que previene el potencial de membrana externa mitocondrial (MOMP) y la fisiÓn mitocondrial, y protege a las células de la liberaciÓn del factor inductor de apoptosis mitocondrial (AIF) y la muerte celular independiente de caspasa en las neuronas. 1].
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Cas No.: 791835-21-7
Sample solution is provided at 25 µL, 10mM.
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BH3-interacting domain (Bid) is cleaved by caspase-8 to produce the truncated protein tBid, which facilitates cytochrome c release from mitochondria and drives apoptosis. BI-6C9 is an inhibitor of tBid (Kd = 20 µM), blocking the release of both cytochrome c and second mitochondria-derived activator of caspase from mitochondria. It prevents apoptosis in neurons treated with glutamate or oxygen-glucose deprivation. BI-6C9 (10 µM) also inhibits the nuclear translocation of apoptosis-inducing factor AIF, preventing the death of ovarian OVCAR-3 cancer cells induced by IFN-α2a.
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