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BI8626

Catalog No.GC65148

BI8626 es un inhibidor especÍfico de la ubiquitina ligasa HUWE1 con una IC50 de 0,9 μM.

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BI8626 Chemical Structure

Cas No.: 1875036-75-1

Tamaño Precio Disponibilidad Cantidad
10mM (in 1mL DMSO)
247,50 $
Disponible
5mg
225,00 $
Disponible
10mg
342,00 $
Disponible
25mg
630,00 $
Disponible
50mg
1.125,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

BI8626 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC50 of 0.9 μM[1].

BI8626 induces HUWE1 ectopically expresses to abolishe ubiquitination of MCL1 in HeLa cells[1].BI8626 suppresses colony formation of Ls174T cells with estimated IC50 value of 0.7 μM, and BI8622 (1-4 days) treatment retards passage of Ls174T cells through all phases of the cell cycle, with the effect being strongest for G1[1].BI8626 (0-50 μM; 0-6 hours) retards the degradation of MCL1 in response to UV irradiation to the same extent as depletion of HUWE1 in U2OS cells[1].

[1]. Peter S, et al. Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase.EMBO Mol Med. 2014 Dec;6(12):1525-41.

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