Biotin-BMCC (Synonyms: (1-Biotinamido)-4-[4'-(maleimidomethyl)cyclohexanecarboxamido]hexane) |
| Catalog No.GC26386 |
Biotin-BMCC is a sulfhydryl-reactive biotinylation reagent with a long spacer arm.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Biotin-BMCC is a sulfhydryl-reactive biotinylation reagent with a long spacer arm. Maleimide-activated reagents are effective for protein modification of sulfhydryl groups. Maleimide groups react efficiently and specifically with free (reduced) sulfhydryls at pH 6.5-7.5 to form stable thioether bonds. Most proteins have cysteine residues whoseside-chain sulfur atoms typically occur in pairs as disulfide bonds. Reduction of these disulfide bonds exposes the sulfhydryl group required as a target for biotinylation with maleimide-activated reagents. Alternatively, sulfhydryl groups can be addedto molecules using various modification reagents.
Biotin-BMCC is not directly soluble in water or aqueous buffers; however, if it is first dissolved in dimethylsulfoxide (DMSO) or other organic solvent, then it can be diluted and remain soluble in an aqueous buffer at typical reaction concentrations.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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