Biotin-NH-PSMA-617 |
| Catalog No.GC62552 |
Biotin-NH-PSMA-617 es un PSMA-617 marcado con biotina. El PSMA-617 es una molécula pequeÑa que se dirige al antÍgeno de membrana especÍfico de la prÓstata (PSMA), que se expresa directamente en las células tumorales.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Biotin-NH-PSMA-617 is a biotin-tagged PSMA-617. PSMA-617 is a small molecule targeting the prostate-specific membrane antigen (PSMA), which is directly expressed by the tumor cells [1].
PSMA-617 is a PSMA ligand. PSMA-617 shows a significantly improved binding affinity to PSMA as well as a highly efficient internalization into PCa cells. PSMA-617 can be labeled with 68Ga, 177Lu, 111In, and 90Y and, therefore, be used for PET-imaging as well as for radioligand-based therapy[1].
[1]. Kratochwil C, et al. Targeted alpha therapy of mCRPC: Dosimetry estimate of 213Bismuth-PSMA-617. Eur J Nucl Med Mol Imaging. 2018;45(1):31-37. [2]. Afshar-Oromieh A, et al. The Theranostic PSMA Ligand PSMA-617 in the Diagnosis of Prostate Cancer by PET/CT: Biodistribution in Humans, Radiation Dosimetry, and First Evaluation of Tumor Lesions. J Nucl Med. 2015;56(11):1697-1705.
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