Boc-C1-PEG3-C4-OBn |
| Catalog No.GC39350 |
Boc-C1-PEG3-C4-OBn (PROTAC Linker 15) es un conector PROTAC, que se refiere a la composiciÓn de PEG. Boc-C1-PEG3-C4-OBn se puede utilizar en la sÍntesis de una serie de PROTAC, como PROTAC SGK3 degradador-1. Los PROTAC contienen dos ligandos diferentes conectados por un enlazador; uno es un ligando para una ubiquitina ligasa E3 y el otro es para la proteÍna diana. Los PROTAC aprovechan el sistema intracelular de ubiquitina-proteasoma para degradar selectivamente las proteÍnas diana.
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Cas No.: 2381196-81-0
Sample solution is provided at 25 µL, 10mM.
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Boc-C1-PEG3-C4-OBn (PROTAC Linker 15) is a PROTAC linker, which refers to the PEG composition. Boc-C1-PEG3-C4-OBn can be used in the synthesis of a series of PROTACs, such as PROTAC SGK3 degrader-1. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTACDegrader. ACS Chem Biol. 2019 Sep 20;14(9):2024-2034.
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