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CAP 2 (hydrochloride) (Synonyms: CAP 2-4,Cholesterol-Amino-Phosphate 2)

Catalog No.GC91828

CAP 2 is an ionizable cationic lipid composed of two cholesterol moieties connected via a phosphate linker that contains an amino head group.

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CAP 2 (hydrochloride) Chemical Structure

Cas No.: N/A

Tamaño Precio Disponibilidad Cantidad
5 mg
139,00 $
Disponible
10 mg
221,00 $
Disponible
25 mg
451,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Description of CAP 2 (hydrochloride)

CAP 2 is an ionizable cationic lipid composed of two cholesterol moieties connected via a phosphate linker that contains an amino head group.[1] It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA or self-amplifying RNA (saRNA) in vivo. It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA or self-amplifying RNA (saRNA) in vivo. LNPs containing CAP 2 and encapsulating saRNA encoding DNA meiotic recombinase 1 (Dmc1) increase Dmc1 levels in seminiferous tubules for a longer period of time than equivalent LNPs encapsulating Dmc1 mRNA in a Dmc1-/- mouse model of male infertility. LNPs containing CAP 2 and encapsulating saRNA encoding Dmc1 increase the percentage of morphologically mature spermatocytes, thickness of the geminate layer, and diameter of the seminiferous tubes in the same mice. Sperm isolated from mice administered these LNPs produced viable embryos with isolated mouse oocytes.

References:
[1].Du, S., Li, W., Zhang, Y., et al.Cholesterol-amino-Phosphate (CAP) derived lipid nanoparticles for delivery of self-amplifying RNA and restoration of spermatogenesis in infertile miceAdv. Sci. (Weinh)10(11)e2300188(2023).

Chemical Properties of CAP 2 (hydrochloride)

Cas No. N/A SDF
Sinónimos CAP 2-4,Cholesterol-Amino-Phosphate 2
Formula C59H102NO4P•HCl M.Wt 956.9
Solubility Chloroform: Sparingly soluble: 1-10 mg/ml Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of CAP 2 (hydrochloride)

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1 mg 5 mg 10 mg
1 mM 1.045 mL 5.2252 mL 10.4504 mL
5 mM 0.209 mL 1.045 mL 2.0901 mL
10 mM 0.1045 mL 0.5225 mL 1.045 mL
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In vivo Formulation Calculator (Clear solution) of CAP 2 (hydrochloride)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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