CAY10621 (Synonyms: SKI 5C, SPHK1 Inhibitor 5C) |
Catalog No.GC43183 |
CAY10621 (SKI 5C; compuesto 5c) es un inhibidor especÍfico de la esfingosina quinasa 1 (SPHK1) con una IC50 de 3,3 μM. CAY10621 es poco tÓxico para las células. CAY10621 tiene el potencial para la investigaciÓn de tumores cancerosos resistentes.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 120005-55-2
Sample solution is provided at 25 µL, 10mM.
CAY10621 is an inhibitor of sphingosine kinase 1 (SPHK1; IC50 = 3.3 μM).[1] It is selective for SPHK1 over SPHK2 at 10 μM and PKC at concentrations less than 100 μM. CAY10621 inhibits SPHK1 activity by 70% in U937 cells when used at a concentration of 5 μM.
Reference:
1. Wong, L., Tan, S.L., Lam, Y., et al. Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases. Journal of Medicinal Chemistry 52, 3618-3626 (2009).
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