Cedazuridine (Synonyms: E7727) |
| Catalog No.GC65934 |
La cedazuridina (E7727) (Compuesto 7a) es un inhibidor de citidina desaminasa (CDA) activo por vÍa oral con un valor IC50 de 0,4 μM. Cedazuridine se puede utilizar para la investigaciÓn del cÁncer.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1141397-80-9
Sample solution is provided at 25 µL, 10mM.
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IC50: 0.4 μM (CDA)[1]
Cedazuridine (E7727) (Compound 7a) is an orally active cytidine deaminase (CDA) inhibitor with an IC50 value of 0.4 μM. Cedazuridine can be used for cancer research[1].
Cedazuridine (Compound 7a) exhibits superior acid stability[1].
Cedazuridine (0-10 μM; 72 h) does not enhance effects of AZA (5-Azacytidine, HY-10586) in growth inhibition of AML cell lines[2].
Cedazuridine (3 mg/kg; p.o.; daily for 7 days) in combination with 2.5 mg/kg AZA shows tumor regression in mice MOLM-13 CDX and PDX models[2].
| Animal Model: | Female NSGS mice, 6-8 weeks old, human cell line-derived (CDX) and primary patient-derived xenograft (PDX) models[2] |
| Dosage: | 3 mg/kg |
| Administration: | Oral administration, in combination with 2.5 mg/kg AZA, daily for 7 days |
| Result: | Led to reduction of leukemic expansion in combination with AZA in a cell line-derived xenograft transplantation, and exhibited preliminary safety and efcacy in a primary AML PDX model. |
| Animal Model: | NSGS male mice[2] |
| Dosage: | 1, 3, 10 and 30 mg/kg |
| Administration: | Oral, in combination with 2.5 mg/kg AZA (Pharmacokinetic Studies) |
| Result: | Dose-dependently increased the AUC of oral AZA and in comparison to dosing of standard i.p. AZA. |
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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