Ceefourin 1 |
Catalog No.GC50287 |
Ceefourin 1 es un potente y altamente selectivo inhibidor de la proteÍna 4 de resistencia a mÚltiples fÁrmacos (MRP4). Ceefourin 1 inhibe el transporte de una amplia gama de sustratos de MRP4, pero es altamente selectivo para MRP4 sobre otros transportadores ABC. Ceefourin 1 es un benzotiazol y principalmente como quimiosensibilizador para el neuroblastoma de alto riesgo.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 315702-40-0
Sample solution is provided at 25 µL, 10mM.
Selective MRP (multidrug resistance-associated protein) 4 inhibitor (IC50 = 2.6 μM). Selective for MRP4 over P-gp, MRP1 and ABCG2. Sensitizes MRP4 over-expressing cells to SN 38 .
Cheung et al (2014) High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4). Biochem.Pharmacol. 91 97 PMID:24973542
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