CHR 6494 trifluoroacetate |
| Catalog No.GC50145 |
El trifluoroacetato CHR 6494 es un potente inhibidor de haspin, con una IC50 de 2 nM. El trifluoroacetato de CHR 6494 inhibe la fosforilaciÓn de la histona H3T3. El trifluoroacetato CHR 6494 induce la apoptosis de las células cancerosas, incluidos el melanoma y el cÁncer de mama. El trifluoroacetato CHR 6494 se puede utilizar en la investigaciÓn del cÁncer.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1458630-17-5
Sample solution is provided at 25 µL, 10mM.
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Potent and selective haspin kinase inhibitor (IC50 = 2 nM). Selective over 27 other protein kinases including Aurora B kinase. Induces cell cycle arrest at G2/M, inhibits cell proliferation and promotes apoptosis in multiple cancer cell lines. Inhibits angiogenesis ex vivo and attenuates tumor growth of HCT-116 xenografts in rats.
Huertas et al (2012) Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin. Oncogene 31 1408 PMID:21804608
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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