CL 075 |
| Catalog No.GC50356 |
CL 075 (3M002) es un agonista selectivo de TLR8 con propiedades inmunomoduladoras.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 256922-53-9
Sample solution is provided at 25 µL, 10mM.
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TLR8 agonist. Induces production of TNF-α and IL-12 from peripheral blood mononuclear cells (PBMCs). Promotes maturation of monocyte-derived dendritic cells in combination with Poly(I:C) (Cat.No.4287).
Gorden et al (2005) Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. J.Immunol. 174 1259 PMID:15661881 |Pang et al (2011) Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytes. BMC Immunol. 12 55 PMID:21962237 |Spranger et al (2010) Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J.Immunol. 185 738 PMID:20511554
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)
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