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CRN04894

Catalog No.GC71439

CRN04894 (compuesto 17h) es un antagonista MC2R activo por vía oral que demuestra la eficacia in vivo en el modelo de rata de la hormona adrenocorticotrópica (ACTH) -estimulada por la secreción de corticosterona.

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CRN04894 Chemical Structure

Cas No.: 2392970-97-5

Tamaño Precio Disponibilidad Cantidad
1 mg
162,00 $
Disponible
5 mg
405,00 $
Disponible
10 mg
648,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents
CRN04894 (compound 17h) is an orally active MC2R antagonist that demonstrates in vivo efficacy in rat model of adrenocorticotropic hormone (ACTH)-stimulated corticosterone secretion[1]. CRN04894 binds to human or rat MC2R with KB values of 0.34 nM and 0.23 nM, respsectively.

CRN04894 (compound 17h) (3, 30 mg/kg; po; single dose) dose-dependently reduces corticosterone secretion levels in an ACTH-stimulated male rat model[1].

References:
[1]. Kim SH, et al. Discovery of CRN04894: A Novel Potent Selective MC2R Antagonist. ACS Med Chem Lett. 2024 Mar 19;15(4):478-485.

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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