Samuraciclib hydrochloride (ICEC0942 hydrochloride) (Synonyms: CT7001 hydrochloride; ICEC0942 hydrochloride) |
| Catalog No.GC32735 |
El clorhidrato de CT7001 (clorhidrato de ICEC0942) (clorhidrato de CT7001) es un inhibidor de CDK7 potente, selectivo, competitivo con ATP y activo por vÍa oral, con una IC50 de 41 nM. El clorhidrato de CT7001 (clorhidrato de ICEC0942) muestra una selectividad de 45, 15, 230 y 30 veces sobre CDK1, CDK2 (IC50 de 578 nM), CDK5 y CDK9, respectivamente. El clorhidrato de CT7001 (clorhidrato de ICEC0942) inhibe el crecimiento de lÍneas celulares de cÁncer de mama con valores de GI50 entre 0,2 y 0,3 μM. El clorhidrato CT7001 (clorhidrato ICEC0942) tiene efectos antitumorales.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1805789-54-1
Sample solution is provided at 25 µL, 10mM.
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CT7001 hydrochloride is a selective CDK7 inhibitor, with IC50s of 41 nM and 578 nM for CDK7/CycH/MAT1 and CDK2/cycE1, respectively.
CT7001 (ICEC0942) is a selective CDK7 inhibitor, with IC50s of 41 nM and 578 nM for CDK7/CycH/MAT1 and CDK2/cycE1, respectively[1].
[1]. Hazel P, et al. Inhibitor Selectivity for Cyclin-Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study. ChemMedChem. 2017 Mar 7;12(5):372-380.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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