CU-CPT8m (Synonyms: TLR8-specific antagonist) |
Catalog No.GC18306 |
CU-CPT8m es un antagonista específico de TLR8, con una IC50 de 67 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 125079-83-6
Sample solution is provided at 25 µL, 10mM.
CU-CPT8m is an antagonist of toll-like receptor 8 (TLR8; Kd = 220 nM; IC50 = 67 nM in a reporter assay). It is selective for TLR8 over a panel of all other human TLRs when used at a concentration of 1 μM. CU-CPT8m (1 μM) inhibits increases in TNF-α and IL-8 mRNA expression induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells. It also inhibits R-848-induced increases in TNF-α protein levels in differentiated THP-1 monocytes and human primary peripheral blood mononuclear cells (PBMCs) in a concentration-dependent manner. CU-CPT8m decreases TNF-α and IL-8 levels in synovial cells derived from patients with osteoarthritis and TNF-α levels in PBMCs derived from patients with rheumatoid arthritis.
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