Cyclopiazonic Acid-13C20 (Synonyms: CPA-13C20) |
| Catalog No.GC47149 |
A neuropeptide with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Cyclopiazonic acid-13C20 is intended for use as an internal standard for the quantification of cyclopiazonic acid by GC- or LC-MS. Cyclopiazonic acid is a mycotoxin that has been found in Penicillium and Aspergillus and an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA; IC50 = 0.6 µM).1,2 In vivo, cyclopiazonic acid (11-14 mg/kg) induces ptosis, hypothermia, tremor, and cachexia, as well as induces lethality (LD50 = 13 mg/kg), in rats.3 It induces tachycardia and sedation in rabbits when administered at a dose of 10 mg/kg.
1.Seidler, N.W., Jona, I., Vegh, M., et al.Cyclopiazonic acid is a specific inhibitor of the Ca2+-ATPase of sarcoplasmic reticulumJ. Biol. Chem.264(30)17816-17823(1989) 2.Uyama, Y., Imaizumi, Y., and Watanabe, M.Effects of cyclopiazonic acid, a novel Ca2+-ATPase inhibitor, on contractile responses in skinned ileal smooth muscleBrit. J. Pharmacol.106(1)208-214(1992) 3.Nishie, K., Cole, R.J., and Dorner, J.W.Toxicity and neuropharmacology of cyclopiazonic acidFood Chem. Toxicol.23(9)831-839(1985)
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *