CYP4A11/CYP4F2-IN-1 |
| Catalog No.GC71173 |
CYP4A11/CYP4F2-IN-1 es un potente inhibidor dual del citocromo P450 (CYP) 4A11 y CYP4F2, con IC50s de 19 nM y 17 nM, respectivamente.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 502654-40-2
Sample solution is provided at 25 µL, 10mM.
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CYP4A11/CYP4F2-IN-1 (compound 2) inhibits 20-Hydroxyeicosatetraenoic acid (20-HETE) production from arachidonic acid in human renal microsomes, with an IC50 of 4.2 nM[1].
References:
[1]. Kawamura M, et, al. Discovery of Novel Pyrazolylpyridine Derivatives for 20-Hydroxyeicosatetraenoic Acid Synthase Inhibitors with Selective CYP4A11/4F2 Inhibition. J Med Chem. 2022 Nov 10;65(21):14599-14613.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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