D-Glucosamine-6-phosphate (hydrate) (Synonyms: D-GlcN-6-P) |
Catalog No.GC47206 |
A neuropeptide with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
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Sample solution is provided at 25 µL, 10mM.
D-Glucosamine-6-phosphate (D-GlcN-6-P) is a monosaccharide intermediate of the hexosamine biosynthetic pathway.1 It is formed from D-fructose-6-phosphate by glucosamine-6-phosphate synthase (GlmS) in the presence of glutamine or from D-glucosamine by N-acetyl-D-glucosamine (GlcNAc) kinase.2,3,4 D-GlcN-6-P binds the GlmS riboswitch (Ki = 380 µM), a ribozyme located in the 5'-UTR of the gene encoding GlmS that, when bound by D-GlcN-6-P, inhibits GlmS production and decreases D-GlcN-6-P levels.2,5 It is a precursor in the biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc), a substrate for protein glycosylation and a component of bacterial cell walls.4,6
1.Buse, M.G.Hexosamines, insulin resistance, and the complications of diabetes: Current statusAm. J. Physiol. Endocrinol. Metab.290(1)E1-E8(2006) 2.Bearne, S.L., and Blouin, C.Inhibition of Escherichia coli glucosamine-6-phosphate synthase by reactive intermediate analogues. The role of the 2-amino function in catalysisJ. Biol. Chem.275(1)135-140(2000) 3.Akella, N.M., Ciraku, L., and Reginato, M.J.Fueling the fire: Emerging role of the hexosamine biosynthetic pathway in cancerBMC Biol.17(1)52(2019) 4.Chiaradonna, F., Ricciardiello, F., and Palorini, R.The nutrient-sensing hexosamine biosynthetic pathway as the hub of cancer metabolic rewiringCells7(6)53(2018) 5.Cochrane, J.C., Lipchock, S.V., and Strobel, S.A.Structural investigation of the GlmS ribozyme bound to its catalytic cofactorChem. Biol.14(1)97-105(2007) 6.RodrÍguez-DÍaz, J., Rubio-Del-Campo, A., and Yebra, M.J.Regulatory insights into the production of UDP-N-acetylglucosamine by Lactobacillus caseiBioengineered3(6)339-342(2012)
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