DB2313 |
| Catalog No.GC62222 |
DB2313 es un potente inhibidor del factor de transcripciÓn PU.1 con una apoptosis de 14 nM. DB2313 interrumpe la interacciÓn de PU.1 con los promotores de genes diana. DB2313 induce la apoptosis de las células de leucemia mieloide aguda (AML) y tiene efectos anticancerÍgenos.
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Cas No.: 2170606-74-1
Sample solution is provided at 25 µL, 10mM.
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DB2313 is a potent transcription factor PU.1 inhibitor with an apoptosis of 14 nM. DB2313 disrupts the interaction of PU.1 with target gene promoters. DB2313 induces apoptosis of acute myeloid leukemia (AML) cells, and has anticancer effects[1].
DB2313 treatment leads to a profound decrease in the growth of PU.1 URE-/- acute myeloid leukemia (AML) cells (IC50 of 7.1 μM), while showing little effect on normal hematopoietic cells at similar concentrations. DB2313 treatment leads to a 3.5-fold increase in apoptotic cells in murine PU.1 URE-/- AML cells. DB2313 also leads to a significant decrease in clonogenicity in the second and third rounds of plating and a complete disruption of clonogenic capacity in the fourth and higher rounds of plating[1].In AML cells, DB2313 decreases PU.1 occupancy on E2f1, Junb, and Csf1r promoters[1].
DB2313 (17 mg/kg; i.p.; three times per week; for 3 weeks) treatment decreases leukemia progression and results in increased survival in mice[1].
[1]. IlÉana Antony-DebrÉ, et al. Pharmacological inhibition of the transcription factor PU.1 in leukemia. J Clin Invest. 2017 Dec 1;127(12):4297-4313.
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