DHODH-IN-12 |
| Catalog No.GC70741 |
DHODH-IN-12 (compuesto 12b) es un derivado de leflunomiy un inhibide la deshidrogenasa dihidroorotato débil (DHODH) con un pKa de 5.07.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1263303-93-0
Sample solution is provided at 25 µL, 10mM.
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Designed a compound structurally related to Leflunomide, containing the furazan ring (Compound 12a), is designed. Compound 12a undergo ring 4 scission under physiological pH conditions to afford the corresponding cyano-oximes DHODH-IN-12 (Compound 12b). DHODH-IN-12 has been assayed as a DHODH inhibitor; its low potency is probably due to the unfavourable stereochemistry of the oxime substructure[1].
References:
[1]. Giorgis M, et al. 1,2,5-Oxadiazole analogues of leflunomide and related compounds. Eur J Med Chem. 2011 Jan;46(1):383-92.
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