E3 ligase Ligand-Linker Conjugates 8 (Synonyms: VH032-C6-PEG3-C4-Cl; VHL Ligand-Linker Conjugates 12; E3 ligase Ligand-Linker Conjugates 8) |
| Catalog No.GC32987 |
Los conjugados ligando-enlazador de E3 ligasa 8 (VH032-C6-PEG3-C4-Cl) son un conjugado de ligandos para E3 y un enlazador de 20 Átomos de longitud. El conector del enlazador es un grupo halÓgeno. Los conjugados ligando-enlazador E3 ligasa 8 incorporan el ligando VHL basado en (S,R,S)-AHPC y un enlazador basado en alquilo/éter. E3 ligase Ligand-Linker Conjugates 8 es capaz de inducir la degradaciÓn de GFP-HaloTag7 en ensayos basados en células.
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Cas No.: 1835705-55-9
Sample solution is provided at 25 µL, 10mM.
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E3 ligase Ligand-Linker Conjugates 8 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.
E3 ligase Ligand-Linker Conjugates 8 uses the cereblon ligand[1]. The linker is 6-2-2-6. The linkers contain a mixture of hydrophobic and hydrophilic moieties to balance the hydrophobicity/hydrophilicity of the resulting hybrid compounds. PROTACs that induce the degradation of an oncogenic tyrosine kinase, BCR-ABL has been developed. E3 ligase Ligand-Linker Conjugates 8 can be attached to potent TKIs (bosutinib and dasatinib) that mediate the degradation of c-ABL and BCR-ABL by hijacking either CRBN or VHL E3 ubiquitin ligase [2].
[1]. US 20170121321 A1 [2]. Lai AC, et al. Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):807-10.
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