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Emamectin B1a (Synonyms: L-656,748)

Catalog No.GC18890

Emamectin B1a is a semi-synthetic derivative of avermectin B1a .

Products are for research use only. Not for human use. We do not sell to patients.

Emamectin B1a Chemical Structure

Cas No.: 121124-29-6

Tamaño Precio Disponibilidad Cantidad
1mg
475,00 $
Disponible
5mg
1.656,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Description of Emamectin B1a

Emamectin B1a is a semi-synthetic derivative of avermectin B1a . It binds to GABAA receptors (Ki = 17.6 nM in rat brain membranes), including those containing β1, β2, or β3 subunits (IC50s = 57, 210, and 49.8 nM for α1β1γ2, α1β2γ2, and α1β3γ2 subunits, respectively), and potentiates the GABA response. Emamectin B1a also binds to and inhibits glycine receptors (IC50 = 218 nM in rat spinal cord). Emamectin B1a induces mortality in 90% of S. exigua larvae in a diet incorporation assay at a dose of 1.067 ng/ml, which is approximately 1,500-fold more toxic than avermectin B1. It is effective against neonate S. eridania larvae in a foliage spray bioassay and when applied topically.

Chemical Properties of Emamectin B1a

Cas No. 121124-29-6 SDF
Sinónimos L-656,748
Chemical Name (4''R)-5-O-demethyl-4''-deoxy-4''-(methylamino)-avermectin A1a
Canonical SMILES N/A
Formula C49H75NO13 M.Wt 886.1
Solubility DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble Storage Store at -20°C, protect from light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Emamectin B1a

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.1285 mL 5.6427 mL 11.2854 mL
5 mM 0.2257 mL 1.1285 mL 2.2571 mL
10 mM 0.1129 mL 0.5643 mL 1.1285 mL
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In vivo Formulation Calculator (Clear solution) of Emamectin B1a

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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Average Rating: 5 ★★★★★ (Based on Reviews and 35 reference(s) in Google Scholar.)

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