Ethionamide-d3 (Synonyms: 2-ethylthioisonicotinamide-d3) |
| Catalog No.GC48947 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2748267-66-3
Sample solution is provided at 25 µL, 10mM.
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Ethionamide-d3 is intended for use as an internal standard for the quantification of ethionamide by GC- or LC-MS. Ethionamide is an antimycobacterial compound that is active against M. tuberculosis (MICs = 0.3-1.25 µg/ml).1,2 It is activated via oxidation by flavin monooxygenase and inhibits the InhA enzyme involved in mycolic acid biosynthesis.1 Formulations containing ethionamide have been used in the second-line treatment of multi-drug resistant tuberculosis.
1.Laborde, J., Deraeve, C., and Bernardes-GÉnisson, V.Update of antitubercular prodrugs from a molecular perspective: Mechanisms of action, bioactivation pathways, and associated resistanceChemMedChem12(20)1657-1676(2017) 2.Heifets, L.B., Lindholm-Levy, P.J., and Flory, M.Comparison of bacteriostatic and bactericidal activity of isoniazid and ethionamide against Mycobacterium avium and Mycobacterium tuberculosisAm. Rev. Respir. Dis.143(2)268-270(1991)
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