FFA3 agonist 1 |
| Catalog No.GC70773 |
FFA3 agonist 1 es un agonista del receptor de ácidos grasos libres 3 (FFA3).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 886358-51-6
Sample solution is provided at 25 µL, 10mM.
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FFA3 agonist 1 (0.01-100 µM) increases the incorporation of [35S]GTPgS and the generation of pERK1/2, reduces the production of cAMP in Flp-In T-REx 293 cells that induced the expression of enhanced yellow fluorescent protein (eYFP) human free fatty acid receptor 3 (hFFA3)[2].
FFA3 agonist 1 (0.1-100 µM) increases the incorporation of [35S]GTPgS in Flp-In T-REx 293 cells induced to express hFFA3, mouse FFA3 (mFFA3) and rat FFA3 (rFFA3)[2].
References:
[1]. Ulven ER, et al. Structure-Activity Relationship Studies of Tetrahydroquinolone Free Fatty Acid Receptor 3 Modulators. J Med Chem. 2020 Apr 9;63(7):3577-3595.
[2]. Hudson BD, Christiansen E, Murdoch H, Jenkins L, Hansen AH, Madsen O, Ulven T, Milligan G. Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands. Mol Pharmacol. 2014 Aug;86(2):200-10.
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