Cyclo(-Ala-Arg-Gly-Asp-3-aminomethylbenzoyl) |
| Catalog No.GA21294 |
The small molecule RGD peptidomimetic αvβ3 integrin antagonist XJ-735 contains both anionic and cationic binding sites that straddle the RGD binding domain of the αvβ3 integrin. The IC?? values of XJ 735 for αvβ3-mediated inhibition of human and porcine cell adhesion, and vascular smooth muscle cell migration, ranged from 0.6 to 4.4 µM. In contrast, IC?? for porcine or human αIIb/β3, α4β1, αvβ5, and α5β1 inhibition exceeded 100 µM.
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Cas No.: 153381-95-4
Sample solution is provided at 25 µL, 10mM.
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The small molecule RGD peptidomimetic αvβ3 integrin antagonist XJ-735 contains both anionic and cationic binding sites that straddle the RGD binding domain of the αvβ3 integrin. The IC50 values of XJ 735 for αvβ3-mediated
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