Hydroxocobalamin acetate |
Catalog No.GC36274 |
El acetato de hidroxocobalamina es una forma natural inyectable de vitamina B12 con un perfil favorable de efectos adversos, que se utiliza como suplemento dietético en la investigaciÓn de la deficiencia de vitamina B12, incluida la anemia perniciosa.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 22465-48-1
Sample solution is provided at 25 µL, 10mM.
Hydroxocobalamin acetate is an injectable naturally occurring form of vitamin B12 with a favorable adverse effect profile, used as a dietary supplement in the treatment of vitamin B12 deficiency including pernicious anemia[1][2]. The cobalt atom of hydroxocobalamin binds cyanide and nitric oxide (NO) and hydroxocobalamin attenuates vascular responses to NO in vitro[3].
[1]. Cheungpasitporn W, et al. High-dose hydroxocobalamin for vasoplegic syndrome causing false blood leak alarm. Clin Kidney J. 2017 Jun;10(3):357-362. [2]. Wang H, et al. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst Rev. 2018 Mar 15;3:CD004655. [3]. Greenberg SS, et al. Hydroxocobalamin (vitamin B12a) prevents and reverses endotoxin-induced hypotension and mortality in rodents: role of nitric oxide. J Pharmacol Exp Ther. 1995 Apr;273(1):257-65.
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