ML367 |
| Catalog No.GC36630 |
ML367 es un potente inhibidor de la estabilizaciÓn de la proteÍna 5 (ATAD5) que contiene el dominio AAA de la familia ATPasa, actÚa como una molécula de sonda que tiene una actividad inhibidora micromolar baja. ML367 bloquea las vÍas de reparaciÓn del ADN, suprime las respuestas generales al daÑo del ADN, incluida la fosforilaciÓn de RPA32 y la fosforilaciÓn de CHK1 en respuesta a la radiaciÓn UV.
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Cas No.: 381168-77-0
Sample solution is provided at 25 µL, 10mM.
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ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization, acts as a probe molecule that has low micromolar inhibitory activity. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation[1]. ATAD5[1]
ML367 (0-40 μM, 16 hours) inhibits FLAG-ATAD5 stabilization in HEK293T cells in the presence or absence of 20 μM 5-FUrd[1]. Western Blot Analysis[1] Cell Line: HEK293T cells
[1]. Rohde JM, et al. Discovery of ML367, inhibitor of ATAD5 stabilization. Probe Reports from the NIH Molecular Libraries Program.
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