PI3Kγ inhibitor 1 |
| Catalog No.GC36910 |
PI3K&2#947; el inhibidor 1 es un inhibidor de PI3Kδ y PI3Kγ extraído de la patente WO2014004470A1, el Compuesto 168 en la Tabla 4, tiene IC50 de \u003c100 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1172118-03-4
Sample solution is provided at 25 µL, 10mM.
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PI3Kγ inhibitor 1 is a PI3Kδ and PI3Kγ inhibitor extracted from patent WO2014004470A1, Compound 168 in Table 4, has IC50s of <100 nM. PI3Kδ|100 nM (IC50)|PI3Kγ|100 nM (IC50)|PI3Kα|10 μM (IC50)|PI3Kβ|10 μM (IC50)
In Table 3, PI3Kγ inhibitor 1 (Compound 168) inhibits PI3Kδ, PI3Kγ, PI3Kα and PI3Kβ with IC50s of <100 nM, <100 nM, <10 μM and <10 μM, respectively. PI3Kγ inhibitor 1 inhibits B cell proliferation with an EC50<100 nM.
[1]. Vito J. Palombella, et al. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using pi3 kinase inhibitors. WO 2014004470 A1.
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