Tubulysin F |
Catalog No.GC37840 |
La tubulisina F es un péptido altamente citotÓxico aislado de las especies mixobacterianas Archangium geophyra y Angiococcus disciformis. La tubulisina muestra una actividad citotÓxica extremadamente potente en células de mamÍferos, incluidas lÍneas celulares multirresistentes, con valores IC50 en el rango nanomolar inferior. La tubulisina F es una tubulisina de actividad citotÓxica que inhibe la polimerizaciÓn de la tubulina y conduce a la detenciÓn del ciclo celular y la apoptosis.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 368870-67-1
Sample solution is provided at 25 µL, 10mM.
Tubulysin F is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range[1]. Tubulysin F is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis[2].
[1]. Kubicek K, et al. The tubulin-bound structure of the antimitotic drug tubulysin. Angew Chem Int Ed Engl. 2010 Jun 28;49(28):4809-12. [2]. Vlahov IR, et al. Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81.
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