VU 6008667 |
| Catalog No.GC37928 |
VU 6008667 es un modulador alostérico negativo selectivo de M5 NAM con IC50 de 1,2 μM y 1,6 μM para M5 humano y M5 de rata, respectivamente.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2092923-21-0
Sample solution is provided at 25 µL, 10mM.
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VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) with IC50s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. VU 6008667 has high CNS penetration[1].
[1]. McGowan KM et al, Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359.
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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