SMCC (Synonyms: NSC 344483, Succinimidyl 4-(N-maleimidomethyl)cyclohexan-1-carboxylate) |
| Catalog No.GC38695 |
SMCC es un reticulador de proteÍnas. Células de bazo acopladas a antÍgeno conjugado con SMCC para inducir respuestas inmunitarias especÍficas de antÍgeno.
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Cas No.: 64987-85-5
Sample solution is provided at 25 µL, 10mM.
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SMCC is a protein crosslinker. SMCC-conjugated antigen coupled spleen cells to induce antigen-specific immune responses[1].
SMCC or sulfo-SMCC can use to conjugate keyhole limpet hemocyanin (KLH) and ovalbumin (OVA). In the the conjugation system, 300 μl KLH or OVA (3 mg) and 30 μl SMCC or Sulfo-SMCC (the final concentration of 0.1 mM) are added in PBS with final volume of 3 ml[1].
Using the SMCC-conjugation method is able to induce potent immune responses to whole protein or peptide antigens by injection of antigen-coupled syngeneic splenic mononuclear cells in mice[1].
[1]. Guo Y, et al. Potent antigen-specific immune response induced by infusion of spleen cells coupled with succinimidyl-4-(N-maleimidomethyl cyclohexane)-1-carboxylate (SMCC) conjugated antigens. Int Immunopharmacol. 2016 Feb;31:158-68.
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