ACTH (1-17) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) (Synonyms: Adrenocorticotropic Hormone (1-17), SYSMEHFRWGKPVGKKR-OH) |
| Catalog No.GC45374 |
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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ACTH (1-17) is a peptide fragment of adrenocorticotropic hormone , a peptide hormone found in the brain that is involved in the biological stress response.1 It binds to melanocortin receptors (MCRs; Kis = 0.23, 14, 419, and 4,240 nM for MC1R, MC3R, MC4R, and MC5R, respectively).2 It is an agonist at MC1R, increasing adenylate cyclase activity with an EC50 value of 3.02 nM in HEK293 cells expressing MC1R.3 ACTH (1-17) (160 μg/kg, i.v.) increases mean arterial blood pressure (MAP) following bleeding-induced hypotension in a rat model of hemorrhagic shock 15-30 minutes after administration.4 It induces melanogenesis in a biphasic manner (EC50s = 0.0001 and 0.08 nM) and differentiation of melanocytes when used at concentrations ranging from 0.01 to 1,000 nM.3,5
References
1. Strand, F.L., Lee, S.J., Zuccarelli, L.A., et al. Non-corticotropic ACTH peptides modulate nerve development and regeneration. Rev. Neurosci. 4(4), 321-363 (1993).
2. Schi•th, H.B., Muceniece, R., Larsson, M., et al. The melanocortin 1, 3, 4 or 5 receptors do not have a binding epitope for ACTH beyond the sequence of α-MSH. J. Endocrinol. 155(1), 73-78 (1997).
3. Tsatmalia, M., Wakamatsu, K., Graham, A.J., et al. Skin POMC peptides. Their binding affinities and activation of the human MC1 receptor. Ann. N.Y. Acad. Sci. 885(1), 466-469 (1999).
4. Bertolini, A., Guarini, S., Rompianesi, E., et al. α-MSH and other ACTH fragments improve cardiovascular function and survival in experimental hemorrhagic shock. Eur. J. Pharmacol. 130(1-2), 19-26 (1986).
5. Hirobe, T., and Hiroyuki, A. ACTH4-12 is the minimal message sequence required to induce the differentiation of mouse epidermal melanocytes in serum-free primary culture. J. Exp. Zool. 286(6), 632-640 (2000).
| Cas No. | SDF | ||
| Sinónimos | Adrenocorticotropic Hormone (1-17), SYSMEHFRWGKPVGKKR-OH | ||
| Canonical SMILES | O=C(C1=C(C)N(C2=C(F)C=CC=C2)N=N1)NC3=CC=C(C=CC=C4)C4=N3 | ||
| Formula | C95H145N29O23S.XCF3COOH | M.Wt | 2093.4 |
| Solubility | DMF: 3mg/mL,DMSO: 15mg/mL,PBS (pH 7.2): 10mg/mL | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 0.4777 mL | 2.3885 mL | 4.7769 mL |
| 5 mM | 0.0955 mL | 0.4777 mL | 0.9554 mL |
| 10 mM | 0.0478 mL | 0.2388 mL | 0.4777 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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