β-Tocopherol-d3 |
Catalog No.GF00010 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 936230-75-0
Sample solution is provided at 25 µL, 10mM.
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
[2]. Azzi A, et, al. d-alpha-tocopherol control of cell proliferation. Mol Aspects Med. 1993; 14(3): 265-71.
[3]. Tasinato A, et, al. d-alpha-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties. Proc Natl Acad Sci U S A. 1995 Dec 19; 92(26): 12190-4.
[4]. Kamei Y, et, al. Comparison of the inhibitory effects of vitamin E analogues on melanogenesis in mouse B16 melanoma cells. Cytotechnology. 2009 Apr; 59(3): 183-90.
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