Thonningianin B |
| Catalog No.GF01060 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 271579-12-5
Sample solution is provided at 25 µL, 10mM.
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Thonningianin B shows strong scavenging action against the DPPH radical. The DPPH radical is scavenged completely by a 34.5 碌M solution of Thonningianin B. In a separate experiment, an IC50 value of Thonningianin B is determined to be 21 渭M[1].
Thonningianin B (0-100 渭M; 24 h) inhibits BV-2 cell viability with an IC50 of 46.74 渭M[2].
Thonningianin B (10 渭M; 24 h) significantly improves the ratio of LC3-II/LC3-I and the average number of GFP-LC3 puncta per cell in BV-2 cells[2].
[1]. Ohtani II, et al. Thonningianins A and B, new antioxidants from the African medicinal herb Thonningia sanguinea. J Nat Prod. 2000 May;63(5):676-9.
[2]. Zhou XG, et al. Targeting microglial autophagic degradation of the NLRP3 inflammasome for identification of thonningianin A in Alzheimer's disease. Inflamm Regen. 2022 Aug 3;42(1):25.
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