GSK-843 (Synonyms: GSK'843) |
| Catalog No.GC34606 |
GSK-843 (GSK'843) es un inhibidor de la proteÍna cinasa 3 que interactÚa con el receptor (RIP3 o RIPK3), que se une al dominio de la cinasa RIP3 con una IC50 de 8,6 nM e inhibe la actividad de la cinasa con una IC50 de 6,5 nM.
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Cas No.: 1601496-05-2
Sample solution is provided at 25 µL, 10mM.
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GSK-843 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM[1]. IC50: 6.5 nM (RIP3)[1]
[1]. Mandal P, et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell. 2014 Nov 20;56(4):481-95.
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