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GSK1034702

Catalog No.GC70269

GSK1034702 es un agonista alostérico M1 mAChR.

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GSK1034702 Chemical Structure

Cas No.: 932373-87-0

Tamaño Precio Disponibilidad Cantidad
5 mg
180,00 $
Disponible
10 mg
288,00 $
Disponible
25 mg
576,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents
GSK1034702 is a M1 mAChR allosteric agonist. GSK1034702 shows procognitive effects in rodents. GSK1034702 modulates hippocampal function to improve memory encoding in nicotine abstinence model of cognitive dysfunction.

References:
[1]. Bradley SJ, et al. Bitopic Binding Mode of an M1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes. Mol Pharmacol. 2018 Jun;93(6):645-656.
[2]. Nathan PJ, et al. The potent M1 receptor allosteric agonist GSK1034702 improves episodic memory in humans in the nicotine abstinence model of cognitive dysfunction. Int J Neuropsychopharmacol. 2013 May;16(4):721-31.

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