HS 38 |
Catalog No.GC50260 |
HS 38 es un inhibidor potente, selectivo y competitivo con ATP de la proteína quinasa 1 asociada a la muerte (DAPK1) y la proteína quinasa que interactúa con la cremallera (ZIPK, también llamada DAPK3), con Kds de 300 nM y 280 nM, respectivamente.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1030203-81-6
Sample solution is provided at 25 µL, 10mM.
ATP-competitive inhibitor of DAPK (IC50 = 200 nM) and ZIPK (Kd = 280 nM). Also inhibits PIM3 kinase (IC50 = 200 nM) but exhibits no significant effect on Src or Abl kinases. Reduces phosphorylation of regulatory myosin light chain and myosin light chain phosphatase in mouse aortic and rabbit ileal tissues.
MacDonald et al (2016) A Small Molecule Pyrazolo[3,4-d]Pyrimidinone Inhibitor of Zipper-Interacting Protein Kinase Suppresses Calcium Sensitization of Vascular Smooth Muscle. Mol.Pharmacol. 89 105 PMID:26464323 |Carlson et al (2013) Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor. ACS.Chem.Biol. 8 2715 PMID:24070067
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