INF 4E |
| Catalog No.GC50368 |
INF 4E es un potente inhibidor del inflamasoma NLRP3.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 88039-46-7
Sample solution is provided at 25 µL, 10mM.
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NLRP3 inflammasome and caspase-1 inhibitor (Ki = 9.6 μM for caspase-1). Inhibits Nigericin or ATP (Cat.No. 3245) induced pyroptosis of PMA-differentiated and LPS-primed THP-1 cells and activates the Keap1-Nrf2 pathway.
Cocco et al (2014) Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis. J.Med.Chem. 57 10366 PMID:25418070
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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